Gallstones

Gallstones are small, hardened deposits that form in the gallbladder, a small organ located beneath the liver that stores bile, the digestive fluid used to break down fats.

Gallstones develop when certain substances in bile, such as cholesterol or bilirubin, become too concentrated and begin to crystallise. Over time, these crystals can grow into stones that vary in size, number, and composition.

Understanding what gallstones are and how they form can help you make sense of the condition and the treatment options available in Singapore.

Types of Gallbladder Stones

Cholesterol Stones

These are the most common types of gallstones. Cholesterol stones form when bile contains more cholesterol than can be dissolved, causing an excess amount to crystallise and gradually form solid stones within the gallbladder.

Pigment Stones

Pigment stones are made primarily of bilirubin, a substance produced when the body breaks down old red blood cells. These stones tend to be darker in colour and may develop in people with certain liver conditions, infections of the bile ducts, or blood disorders that increase bilirubin levels.

Causes of Gallstones

Gallstones can develop when the normal movement and storage of bile in the gallbladder is disrupted.

Bile is produced by the liver and stored in the gallbladder before being released into the small intestine to help digest fats. When this system does not function as it should, bile can remain in the gallbladder for longer than usual, allowing solid particles to gradually develop.

Several factors may contribute to this process:

  • When the gallbladder does not empty fully during digestion, bile can remain inside for longer periods and become more concentrated.
  • Hormones such as oestrogen can change how bile is produced and stored, which may increase the chance of gallstones forming.
  • Your body weight and metabolism can affect how the body processes fats and bile.
  • Losing weight quickly can change how the liver releases bile, which may increase the risk of gallstones forming.
  • Some liver diseases, blood disorders, or digestive conditions can influence bile composition or flow.
  • Diets that are very high in fat or refined carbohydrates, or very low in fibre, may contribute to changes in bile balance over time.
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Common Symptoms of Gallstones

Here’s what you may experience if you have gallstones:

  • Sudden pain in the right upper abdomen
  • Pain in the centre of the abdomen below the breastbone (epigastric pain)
  • Pain that spreads from the abdomen to the back
  • Pain that radiates to the right shoulder
  • Abdominal bloating, which may feel worse after meals or at night
  • Nausea and vomiting

More severe symptoms may indicate complications from the stones found in your gallbladder and require treatment. These may include:

  • Severe abdominal pain
  • Fever
  • Jaundice (yellowing of the skin or eyes)

It’s also possible to have gallstones without experiencing any symptoms. In many cases, gallstones are discovered incidentally during imaging tests performed for other medical reasons.

Who Is at Risk of Developing Gallstones?

You may have a higher likelihood of developing gallstones if you:

  • Are female, as hormonal changes can affect bile composition
  • Are over 40 years old
  • Have a family history of gallstones
  • Are overweight or obese
  • Have experienced rapid weight loss
  • Are pregnant
  • Have certain medical conditions, such as liver disease, diabetes, or blood disorders
  • Follow a diet high in fat or refined carbohydrates and low in fibre

Gallbladder Stones Diagnosis

At Digestive & Liver Surgery, we typically begin with a clinical assessment and imaging tests to confirm the presence of stones and evaluate your gallbladder and bile ducts.

Depending on your symptoms and medical history, you may be asked to undergo one or more of the following investigations:

  • Ultrasound is usually the first test performed. It allows us to visualise gallstones, assess their size and number, and examine the gallbladder.
  • CT or MRI scans to evaluate abdominal pain further or to identify complications related to gallstone disease.
  • Blood tests, which help us check for signs of infection, inflammation, bile duct obstruction, pancreatitis, or jaundice.
  • Endoscopic ultrasound (EUS): During this procedure, a thin endoscope is passed through the mouth into the stomach and the first part of the small intestine (duodenum). This allows us to obtain detailed images and detect stones that may be located in the bile ducts.
  • Endoscopic retrograde cholangiopancreatography (ERCP): If stones are found in the bile duct, this may be performed to locate and remove them during the same procedure.
Gallstones Treatment

Your treatment will depend largely on whether your gallstones are causing symptoms.

Monitoring for Asymptomatic Gallstones

If gallstones are detected during an ultrasound but you don’t experience symptoms, treatment is usually not required. Monitoring your condition may be sufficient.

If gallstones begin to cause pain or complications, gallbladder removal surgery may be recommended as part of your treatment plan. Surgery may also be considered if you have certain medical conditions, such as haemolytic anaemia, or if there’s an increased risk of gallbladder cancer.

In most cases, we perform cholecystectomy using laparoscopic (keyhole) surgery. During the procedure, we remove the gallbladder through several small incisions in your abdomen using specialised instruments.

You may be able to return home on the same day or after an overnight stay in the hospital, depending on your recovery.

In more complex cases, an open surgical procedure may be required. This involves a larger incision in the abdomen and usually requires a longer hospital stay.

What Are the Complications of Gallstones?

Gallstones with complications are usually treated as emergency cases. These include:

  • Cholecystitis (gallbladder inflammation): When a gallstone blocks the opening of the gallbladder, leading to inflammation and persistent abdominal pain.
  • Bile duct obstruction (choledocholithiasis): A gallstone may move from the gallbladder into the bile duct and block the flow of bile.
  • Pancreatitis: If a gallstone blocks the pancreatic duct, it can trigger inflammation of the pancreas.
  • Cholangitis: Infection can develop in the bile ducts if bile flow is blocked for a prolonged period.

How to Prevent Gallstones

Gallstones cannot always be prevented, but certain lifestyle habits may help reduce your risk.

Maintaining a healthy body weight and eating a balanced diet can support normal bile function.

Rapid weight loss and crash dieting can increase the risk of gallstones, so gradual and sustainable weight management is generally recommended.

Ongoing Gallbladder Pain or Gallstones?

Gallstones can lead to recurring pain or complications if they continue to block the flow of bile. Speak with our surgeons at Digestive & Liver Surgery to determine what kind of gallstones treatment you need.

Frequently Asked Questions

Can gallstones go away naturally?

No, gallstones usually don’t go away on their own. Once formed, they tend to remain in the gallbladder unless they are removed or pass into the bile ducts.

Untreated gallstones may lead to gallbladder infection, bile duct obstruction, or pancreatitis.

Yes, it can be safe to live with gallstones if they do not cause symptoms. In such cases, we may recommend monitoring rather than surgery unless pain or complications develop.

Non-surgical treatments are limited and are not suitable for most patients. Surgery to remove the gallbladder is an effective way to treat symptomatic gallstones.

Surgery is usually recommended when gallstones cause symptoms or complications rather than based on their size alone. Recurrent pain, inflammation, or bile duct blockage are common reasons surgery may be recommended.

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Gleneagles Hospital

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